Assay Detail
Binding
CHEMBL831068
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Inhibitory concentration against Aggrecanase
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of 3,3-dimethyl-5-hydroxypipecolic hydroxamate-based inhibitors of aggrecanase and MMP-13.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.85 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL372878 | — | — | 1 | 9.30 |
| CHEMBL179552 | — | — | 1 | 8.68 |
| CHEMBL190415 | — | — | 1 | 8.57 |
| CHEMBL189216 | — | — | 1 | 8.41 |
| CHEMBL190506 | — | — | 1 | 7.82 |
| CHEMBL372261 | — | — | 1 | 7.80 |
| CHEMBL190686 | — | — | 1 | 7.75 |
| CHEMBL190563 | — | — | 1 | 7.42 |
| CHEMBL189052 | — | — | 1 | 7.40 |
| CHEMBL189156 | — | — | 1 | 7.17 |
| CHEMBL192309 | — | — | 1 | 7.04 |
| CHEMBL191030 | — | — | 1 | 6.84 |
| CHEMBL192773 | — | — | 1 | - |
| CHEMBL370312 | — | — | 1 | - |
| CHEMBL189975 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL372878 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL179552 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL190415 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL189216 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL190506 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL372261 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL190686 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL190563 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL189052 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL189156 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL192309 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL191030 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL192773 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL370312 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL189975 | — | IC50 | > | 100.0 | nM | - |