Assay Detail
Binding
CHEMBL831101
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Inhibitory activity against human Endothelial nitric oxide synthase (eNOS)
13
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inhibitors of inducible nitric oxide synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.67 | 6.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6808 | — | — | 1 | 6.84 |
| CHEMBL191242 | — | — | 2 | 6.44 |
| CHEMBL269058 | — | — | 1 | 6.20 |
| CHEMBL191675 | — | — | 1 | 6.08 |
| CHEMBL433589 | — | — | 1 | 6.06 |
| CHEMBL365804 | — | — | 1 | 5.70 |
| CHEMBL190655 | — | — | 1 | 5.35 |
| CHEMBL193007 | — | — | 1 | 5.26 |
| CHEMBL364230 | — | — | 1 | 4.90 |
| CHEMBL192033 | — | — | 1 | 4.82 |
| CHEMBL6656 | — | — | 1 | 4.07 |
| CHEMBL370922 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6808 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL191242 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL191242 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL269058 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL191675 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL433589 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL365804 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL190655 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL193007 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL364230 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL192033 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL6656 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL370922 | — | IC50 | > | 5000.0 | nM | - |