Assay Detail
Binding
CHEMBL831106
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Inhibitory concentration against Nicotinic acetylcholine receptor alpha 7
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL2492) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.24 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL412032 | — | — | 1 | 9.52 |
| CHEMBL437423 | — | — | 1 | 8.96 |
| CHEMBL451252 | — | — | 1 | 7.52 |
| CHEMBL191491 | STILONIUM | 2.0 | 1 | 6.96 |
| CHEMBL439347 | — | — | 1 | 6.36 |
| CHEMBL188383 | — | — | 1 | 5.07 |
| CHEMBL267936 | MECAMYLAMINE | 4.0 | 1 | 4.91 |
| CHEMBL405936 | — | — | 1 | 4.83 |
| CHEMBL894 | BUPROPION | 4.0 | 1 | 4.30 |
| CHEMBL335712 | — | — | 1 | 4.01 |
| CHEMBL510275 | METHYLLYCACONITINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL412032 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL437423 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL451252 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL191491 | STILONIUM | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL439347 | — | IC50 | = | 441.0 | nM | 6.36 |
| CHEMBL188383 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL267936 | MECAMYLAMINE | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL405936 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL894 | BUPROPION | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL335712 | — | IC50 | = | 98000.0 | nM | 4.01 |
| CHEMBL510275 | METHYLLYCACONITINE | IC50 | > | 1000.0 | nM | - |