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Assay Detail

CHEMBL831140

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory concentration against human placental aromatase by deutirium oxide release
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Aromatase (CHEMBL1978)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and characterization of azole isoflavone inhibitors of aromatase.
Hackett JC, Kim YW, Su B, Brueggemeier RW.
Bioorg Med Chem Lett (2005) 15 : 4063 -4070
PubMed 15911319 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 5.46 6.28

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL363493 1 6.28
CHEMBL192306 1 6.11
CHEMBL189472 1 5.70
CHEMBL488 AMINOGLUTETHIMIDE 4.0 1 5.55
CHEMBL189274 1 5.33
CHEMBL190099 1 4.75
CHEMBL131921 BIOCHANIN 1 4.47
CHEMBL191488 1 -
CHEMBL190848 1 -
CHEMBL190208 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL363493 IC50 = 520.0 nM 6.28
CHEMBL192306 IC50 = 770.0 nM 6.11
CHEMBL189472 IC50 = 2000.0 nM 5.70
CHEMBL488 AMINOGLUTETHIMIDE IC50 = 2800.0 nM 5.55
CHEMBL189274 IC50 = 4700.0 nM 5.33
CHEMBL190099 IC50 = 18000.0 nM 4.75
CHEMBL131921 BIOCHANIN IC50 = 34000.0 nM 4.47
CHEMBL191488 IC50 > 50000.0 nM -
CHEMBL190848 IC50 > 50000.0 nM -
CHEMBL190208 IC50 > 50000.0 nM -