Assay Detail
Binding
CHEMBL831431
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Inhibition of alpha IIb beta3 integrin receptor in human platelet rich plasma
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Ligand binding analysis for human alpha5beta1 integrin: strategies for designing new alpha5beta1 integrin antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.12 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL126416 | — | — | 1 | 5.85 |
| CHEMBL339751 | — | — | 1 | 5.25 |
| CHEMBL340309 | — | — | 1 | 5.14 |
| CHEMBL364063 | — | — | 1 | 5.14 |
| CHEMBL2096812 | — | — | 1 | 5.04 |
| CHEMBL126983 | — | — | 1 | 4.96 |
| CHEMBL338806 | — | — | 1 | 4.47 |
| CHEMBL338439 | — | — | 1 | - |
| CHEMBL435806 | — | — | 1 | - |
| CHEMBL126071 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL126416 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL339751 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL340309 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL364063 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL2096812 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL126983 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL338806 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL338439 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL435806 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL126071 | — | IC50 | > | 100000.0 | nM | - |