Assay Detail
Binding
CHEMBL831436
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Inhibitory concentration required to inhibit HCV RNA dependent RNA polymerase Nonstructural protein 5B in the presence of Mn2+ is determined
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepacivirus hominis |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
RNA-directed RNA polymerase (CHEMBL4296320) ↗| Type | SINGLE PROTEIN |
| Organism | Hepacivirus hominis |
Publication
HCV NS5b RNA-dependent RNA polymerase inhibitors: from alpha,gamma-diketoacids to 4,5-dihydroxypyrimidine- or 3-methyl-5-hydroxypyrimidinonecarboxylic acids. Design and synthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.71 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL364321 | — | — | 1 | 6.22 |
| CHEMBL188307 | — | — | 1 | 6.00 |
| CHEMBL359981 | — | — | 1 | 6.00 |
| CHEMBL188448 | — | — | 1 | 5.85 |
| CHEMBL440562 | — | — | 1 | 5.64 |
| CHEMBL188277 | — | — | 1 | 4.52 |
| CHEMBL362571 | — | — | 1 | - |
| CHEMBL186437 | — | — | 1 | - |
| CHEMBL188428 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL364321 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL188307 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL359981 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL188448 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL440562 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL188277 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL362571 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL186437 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL188428 | — | IC50 | > | 50000.0 | nM | - |