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Assay Detail

CHEMBL831582

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory concentration against human Protein kinase B, Akt3
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

RAC-gamma serine/threonine-protein kinase (CHEMBL4816)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors.
Lindsley CW, Zhao Z, Leister WH, Robinson RG, Barnett SF, Defeo-Jones D, Jones RE, Hartman GD, Huff JR, Huber HE, Duggan ME.
Bioorg Med Chem Lett (2005) 15 : 761 -764
PubMed 15664853 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 5.38 5.91

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL271091 1 5.91
CHEMBL408151 1 5.79
CHEMBL258844 1 5.67
CHEMBL180231 1 5.62
CHEMBL273160 1 5.50
CHEMBL3143722 1 5.40
CHEMBL178468 1 4.66
CHEMBL572629 1 4.48
CHEMBL260397 1 -
CHEMBL577792 1 -
CHEMBL178397 1 -
CHEMBL180580 1 -
CHEMBL178133 1 -
CHEMBL3143723 1 -
CHEMBL440560 1 -
CHEMBL428861 1 -
CHEMBL362455 1 -
CHEMBL362016 1 -
CHEMBL272292 1 -
CHEMBL181419 1 -
CHEMBL180058 1 -
CHEMBL3143721 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL271091 IC50 = 1228.0 nM 5.91
CHEMBL408151 IC50 = 1613.0 nM 5.79
CHEMBL258844 IC50 = 2119.0 nM 5.67
CHEMBL180231 IC50 = 2400.0 nM 5.62
CHEMBL273160 IC50 = 3200.0 nM 5.50
CHEMBL3143722 IC50 = 3973.0 nM 5.40
CHEMBL178468 IC50 = 21870.0 nM 4.66
CHEMBL572629 IC50 = 33100.0 nM 4.48
CHEMBL260397 IC50 > 50000.0 nM -
CHEMBL577792 IC50 > 50000.0 nM -
CHEMBL178397 IC50 > 50000.0 nM -
CHEMBL180580 IC50 > 50000.0 nM -
CHEMBL178133 IC50 > 50000.0 nM -
CHEMBL3143723 IC50 > 50000.0 nM -
CHEMBL440560 IC50 > 50000.0 nM -
CHEMBL428861 IC50 > 50000.0 nM -
CHEMBL362455 IC50 > 50000.0 nM -
CHEMBL362016 IC50 > 50000.0 nM -
CHEMBL272292 IC50 > 50000.0 nM -
CHEMBL181419 IC50 > 50000.0 nM -
CHEMBL180058 IC50 > 50000.0 nM -
CHEMBL3143721 IC50 > 50000.0 nM -