Assay Detail
Binding
CHEMBL831691
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Inhibition of human phosphodiesterase 4
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Optimization of purine based PDE1/PDE5 inhibitors to a potent and selective PDE5 inhibitor for the treatment of male ED.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.41 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL373102 | — | — | 1 | 5.85 |
| CHEMBL1520 | VARDENAFIL | 4.0 | 1 | 5.35 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 5.02 |
| CHEMBL779 | TADALAFIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL373102 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1520 | VARDENAFIL | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL192 | SILDENAFIL | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL779 | TADALAFIL | IC50 | > | 10000.0 | nM | - |