Assay Detail
Binding
CHEMBL831693
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human phosphodiesterase 6
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Optimization of purine based PDE1/PDE5 inhibitors to a potent and selective PDE5 inhibitor for the treatment of male ED.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.34 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1520 | VARDENAFIL | 4.0 | 1 | 9.00 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 7.60 |
| CHEMBL373102 | — | — | 1 | 6.75 |
| CHEMBL779 | TADALAFIL | 4.0 | 1 | 6.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1520 | VARDENAFIL | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL192 | SILDENAFIL | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL373102 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL779 | TADALAFIL | IC50 | = | 980.0 | nM | 6.01 |