Assay Detail
Binding
CHEMBL831700
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Inhibitory concentration against Endothelial nitric oxide synthase
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.07 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL362772 | — | — | 1 | 6.35 |
| CHEMBL186431 | — | — | 1 | 6.00 |
| CHEMBL185833 | — | — | 1 | 5.96 |
| CHEMBL187008 | — | — | 1 | 5.39 |
| CHEMBL364999 | — | — | 1 | 5.30 |
| CHEMBL365202 | — | — | 1 | 5.30 |
| CHEMBL361722 | — | — | 1 | 5.22 |
| CHEMBL7889 | L-NIL | — | 1 | 5.10 |
| CHEMBL186856 | — | — | 1 | 4.98 |
| CHEMBL88308 | — | — | 1 | 4.87 |
| CHEMBL330548 | — | — | 1 | 4.60 |
| CHEMBL186969 | — | — | 1 | 4.30 |
| CHEMBL186985 | — | — | 1 | 4.30 |
| CHEMBL185919 | — | — | 1 | 4.22 |
| CHEMBL186091 | — | — | 1 | 4.11 |
| CHEMBL186360 | — | — | 1 | - |
| CHEMBL188073 | — | — | 1 | - |
| CHEMBL361049 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL362772 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL186431 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL185833 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL187008 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL364999 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL365202 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL361722 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL7889 | L-NIL | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL186856 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL88308 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL330548 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL186969 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL186985 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL185919 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL186091 | — | IC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL186360 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL188073 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL361049 | — | IC50 | > | 50000.0 | nM | - |