Assay Detail
Binding
CHEMBL831870
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125 I-Tyr4]BB from human gastrin releasing peptide receptor expressed in PC-3 cell membranes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Potent bombesin-like peptides for GRP-receptor targeting of tumors with 99mTc: a preclinical study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 9.69 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2371725 | Demobesin 3 | — | 1 | 10.22 |
| CHEMBL414307 | — | — | 1 | 10.10 |
| CHEMBL2371724 | — | — | 1 | 9.82 |
| CHEMBL266079 | — | — | 1 | 9.22 |
| CHEMBL2371726 | — | — | 1 | 9.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2371725 | Demobesin 3 | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL414307 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL2371724 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL266079 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL2371726 | — | IC50 | = | 0.85 | nM | 9.07 |