Assay Detail
Binding
CHEMBL831871
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Inhibitory activity against 20-Hydroxy-5,8,11,14-eicosatetraenoic acid synthase from arachidonic acid in rat renal microsome
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and synthesis of 1-(4-benzoylphenyl)imidazole derivatives as new potent 20-HETE synthase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.40 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1627054 | — | — | 1 | 7.89 |
| CHEMBL267865 | — | — | 1 | 7.45 |
| CHEMBL363500 | — | — | 1 | 6.51 |
| CHEMBL184786 | — | — | 1 | 5.70 |
| CHEMBL184043 | — | — | 1 | 5.70 |
| CHEMBL184045 | — | — | 1 | 5.12 |
| CHEMBL182310 | — | — | 1 | - |
| CHEMBL362271 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1627054 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL267865 | — | IC50 | = | 35.2 | nM | 7.45 |
| CHEMBL363500 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL184786 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL184043 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL184045 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL182310 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL362271 | — | IC50 | > | 5000.0 | nM | - |