Assay Detail
Binding
CHEMBL832081
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Inhibitory concentration against dual-specificity phosphatase Cell division cycle (Cdc) 25A
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of novel Cdc25A-inhibitors having phosphate group as a hydrophilic residue.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.21 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182645 | — | — | 1 | 6.16 |
| CHEMBL179992 | — | — | 1 | 6.05 |
| CHEMBL181815 | — | — | 1 | 5.41 |
| CHEMBL181850 | — | — | 1 | 5.26 |
| CHEMBL182548 | — | — | 1 | 5.26 |
| CHEMBL181800 | — | — | 1 | 5.16 |
| CHEMBL362416 | — | — | 1 | 5.09 |
| CHEMBL182673 | — | — | 1 | 5.07 |
| CHEMBL1765353 | DYSIDIOLIDE | — | 1 | 5.03 |
| CHEMBL332036 | — | — | 1 | 4.76 |
| CHEMBL181052 | — | — | 1 | 4.64 |
| CHEMBL181402 | — | — | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182645 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL179992 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL181815 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL181850 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL182548 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL181800 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL362416 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL182673 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL1765353 | DYSIDIOLIDE | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL332036 | — | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL181052 | — | IC50 | = | 22700.0 | nM | 4.64 |
| CHEMBL181402 | — | IC50 | = | 24500.0 | nM | 4.61 |