Assay Detail
Binding
CHEMBL832269
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of human Phosphodiesterase 3A3 expressed in baculovirus infected Sf9 cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (CHEMBL241) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.73 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185296 | — | — | 1 | 6.55 |
| CHEMBL185208 | — | — | 1 | 4.95 |
| CHEMBL184945 | — | — | 1 | 4.83 |
| CHEMBL427505 | — | — | 1 | 4.78 |
| CHEMBL185304 | — | — | 1 | 4.67 |
| CHEMBL183465 | — | — | 1 | 4.53 |
| CHEMBL185370 | — | — | 1 | 4.50 |
| CHEMBL366149 | — | — | 1 | 4.38 |
| CHEMBL361469 | — | — | 1 | 4.35 |
| CHEMBL427513 | — | — | 1 | 4.35 |
| CHEMBL182617 | — | — | 1 | 4.11 |
| CHEMBL185588 | — | — | 1 | - |
| CHEMBL363084 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185296 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL185208 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL184945 | — | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL427505 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL185304 | — | IC50 | = | 21300.0 | nM | 4.67 |
| CHEMBL183465 | — | IC50 | = | 29300.0 | nM | 4.53 |
| CHEMBL185370 | — | IC50 | = | 31600.0 | nM | 4.50 |
| CHEMBL366149 | — | IC50 | = | 42200.0 | nM | 4.38 |
| CHEMBL361469 | — | IC50 | = | 45100.0 | nM | 4.35 |
| CHEMBL427513 | — | IC50 | = | 44500.0 | nM | 4.35 |
| CHEMBL182617 | — | IC50 | = | 78100.0 | nM | 4.11 |
| CHEMBL185588 | — | IC50 | > | 92000.0 | nM | - |
| CHEMBL363084 | — | IC50 | > | 79900.0 | nM | - |