Assay Detail
Binding
CHEMBL832270
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In vitro inhibition of human Phosphodiesterase 4D3 expressed in baculovirus infected Sf9 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
3',5'-cyclic-AMP phosphodiesterase 4D (CHEMBL288) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.81 | 6.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185304 | — | — | 1 | 6.33 |
| CHEMBL427505 | — | — | 1 | 6.13 |
| CHEMBL185208 | — | — | 1 | 6.00 |
| CHEMBL185370 | — | — | 1 | 5.88 |
| CHEMBL182617 | — | — | 1 | 5.84 |
| CHEMBL427513 | — | — | 1 | 5.82 |
| CHEMBL184945 | — | — | 1 | 5.81 |
| CHEMBL363084 | — | — | 1 | 5.80 |
| CHEMBL366149 | — | — | 1 | 5.79 |
| CHEMBL183465 | — | — | 1 | 5.77 |
| CHEMBL361469 | — | — | 1 | 5.75 |
| CHEMBL185588 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185304 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL427505 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL185208 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL185370 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL182617 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL427513 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL184945 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL363084 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL366149 | — | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL183465 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL361469 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL185588 | — | IC50 | = | 15700.0 | nM | 4.80 |