Assay Detail
Binding
CHEMBL832271
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In vitro inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A (CHEMBL3012) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.56 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185304 | — | — | 1 | 8.00 |
| CHEMBL182617 | — | — | 1 | 8.00 |
| CHEMBL183465 | — | — | 1 | 8.00 |
| CHEMBL427505 | — | — | 1 | 7.70 |
| CHEMBL185296 | — | — | 1 | 7.70 |
| CHEMBL366149 | — | — | 1 | 7.70 |
| CHEMBL363084 | — | — | 1 | 7.70 |
| CHEMBL427513 | — | — | 1 | 7.70 |
| CHEMBL361469 | — | — | 1 | 7.52 |
| CHEMBL185208 | — | — | 1 | 7.52 |
| CHEMBL184945 | — | — | 1 | 7.30 |
| CHEMBL185588 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185304 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL182617 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL183465 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL427505 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL185296 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL366149 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL363084 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL427513 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL361469 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL185208 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL184945 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL185588 | — | IC50 | = | 1520.0 | nM | 5.82 |