Assay Detail
Binding
CHEMBL832300
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against human glutathione reductase in the absence of glucose-6-phosphate dehydrogenase (G6PDH)
2
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Glutathione reductase, mitochondrial (CHEMBL2755) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
5-substituted tetrazoles as bioisosteres of carboxylic acids. Bioisosterism and mechanistic studies on glutathione reductase inhibitors as antimalarials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.66 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135287 | — | — | 2 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135287 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL135287 | — | IC50 | = | 2700.0 | nM | 5.57 |