Assay Detail
Binding
CHEMBL832321
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of [1,2,6,7-3H]androstenedione binding to Aromatase of human placental microsomes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and evaluation of 4-triazolylflavans as new aromatase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.23 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95919 | — | — | 1 | 7.40 |
| CHEMBL95109 | — | — | 1 | 7.05 |
| CHEMBL187185 | — | — | 1 | 6.37 |
| CHEMBL185165 | — | — | 1 | 5.85 |
| CHEMBL184952 | — | — | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95919 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL95109 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL187185 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL185165 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL184952 | — | IC50 | = | 31600.0 | nM | 4.50 |