Assay Detail
Binding
CHEMBL832326
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Concentration required to inhibit binding of [125I]MCH radioligand to human melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes
57
Total Activities
55
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Melanin-concentrating hormone receptor 1 (CHEMBL344) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 57 | 6.57 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL183159 | — | — | 3 | 7.70 |
| CHEMBL362713 | — | — | 1 | 7.50 |
| CHEMBL362720 | — | — | 1 | 7.44 |
| CHEMBL186770 | — | — | 1 | 7.28 |
| CHEMBL184520 | — | — | 1 | 7.22 |
| CHEMBL364377 | — | — | 1 | 7.05 |
| CHEMBL187702 | — | — | 1 | 6.98 |
| CHEMBL363311 | — | — | 1 | 6.94 |
| CHEMBL361288 | — | — | 1 | 6.88 |
| CHEMBL184394 | — | — | 1 | 6.86 |
| CHEMBL186750 | — | — | 1 | 6.86 |
| CHEMBL186818 | — | — | 1 | 6.76 |
| CHEMBL365459 | — | — | 1 | 6.72 |
| CHEMBL364104 | — | — | 1 | 6.70 |
| CHEMBL185095 | — | — | 1 | 6.70 |
| CHEMBL187859 | — | — | 1 | 6.51 |
| CHEMBL184446 | — | — | 1 | 6.51 |
| CHEMBL185096 | — | — | 1 | 6.49 |
| CHEMBL184573 | — | — | 1 | 6.46 |
| CHEMBL185235 | — | — | 1 | 6.44 |
| CHEMBL184980 | — | — | 1 | 6.37 |
| CHEMBL365254 | — | — | 1 | 6.36 |
| CHEMBL186949 | — | — | 1 | 6.31 |
| CHEMBL186481 | — | — | 1 | 6.24 |
| CHEMBL363011 | — | — | 1 | 6.22 |
| CHEMBL184476 | — | — | 1 | 6.21 |
| CHEMBL183932 | — | — | 1 | 6.19 |
| CHEMBL187165 | — | — | 1 | 6.14 |
| CHEMBL186659 | — | — | 1 | 6.10 |
| CHEMBL187295 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL183159 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL362713 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL362720 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL183159 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL186770 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL184520 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL364377 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL187702 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL363311 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL361288 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL184394 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL186750 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL186818 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL365459 | — | IC50 | = | 191.0 | nM | 6.72 |
| CHEMBL185095 | — | IC50 | = | 199.0 | nM | 6.70 |
| CHEMBL364104 | — | IC50 | = | 201.0 | nM | 6.70 |
| CHEMBL187859 | — | IC50 | = | 306.0 | nM | 6.51 |
| CHEMBL184446 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL185096 | — | IC50 | = | 326.0 | nM | 6.49 |
| CHEMBL184573 | — | IC50 | = | 349.0 | nM | 6.46 |
| CHEMBL185235 | — | IC50 | = | 361.0 | nM | 6.44 |
| CHEMBL184980 | — | IC50 | = | 432.0 | nM | 6.37 |
| CHEMBL365254 | — | IC50 | = | 437.0 | nM | 6.36 |
| CHEMBL186949 | — | IC50 | = | 492.0 | nM | 6.31 |
| CHEMBL183159 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL186481 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL363011 | — | IC50 | = | 606.0 | nM | 6.22 |
| CHEMBL184476 | — | IC50 | = | 614.0 | nM | 6.21 |
| CHEMBL183932 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL187165 | — | IC50 | = | 722.0 | nM | 6.14 |
| CHEMBL186659 | — | IC50 | = | 789.0 | nM | 6.10 |
| CHEMBL184102 | — | IC50 | = | 808.0 | nM | 6.09 |
| CHEMBL187295 | — | IC50 | = | 818.0 | nM | 6.09 |
| CHEMBL183739 | — | IC50 | = | 823.0 | nM | 6.08 |
| CHEMBL184001 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL427153 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL77072 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL186547 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL363222 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL186771 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL183532 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL185065 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL363120 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL366307 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL426971 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL185187 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL181798 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL119647 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL366041 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL184086 | — | IC50 | > | 2000.0 | nM | - |