Assay Detail
Binding
CHEMBL832348
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 6.88 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL186342 | — | — | 1 | 8.30 |
| CHEMBL186898 | — | — | 1 | 8.15 |
| CHEMBL364213 | — | — | 1 | 8.10 |
| CHEMBL363954 | — | — | 1 | 8.00 |
| CHEMBL186470 | — | — | 1 | 7.92 |
| CHEMBL184404 | — | — | 1 | 7.89 |
| CHEMBL187256 | — | — | 1 | 7.89 |
| CHEMBL187903 | — | — | 1 | 7.89 |
| CHEMBL186240 | — | — | 1 | 7.80 |
| CHEMBL365855 | — | — | 1 | 7.60 |
| CHEMBL186371 | — | — | 1 | 7.39 |
| CHEMBL359591 | — | — | 1 | 7.36 |
| CHEMBL187015 | — | — | 1 | 7.36 |
| CHEMBL364338 | — | — | 1 | 7.32 |
| CHEMBL426972 | — | — | 1 | 7.19 |
| CHEMBL186511 | — | — | 1 | 7.19 |
| CHEMBL185734 | — | — | 1 | 7.04 |
| CHEMBL186510 | — | — | 1 | 6.99 |
| CHEMBL185470 | — | — | 1 | 6.74 |
| CHEMBL363283 | — | — | 1 | 6.72 |
| CHEMBL363711 | — | — | 1 | 6.49 |
| CHEMBL186846 | — | — | 1 | 6.41 |
| CHEMBL185498 | — | — | 1 | 6.21 |
| CHEMBL186201 | — | — | 1 | 6.05 |
| CHEMBL188172 | — | — | 1 | 5.94 |
| CHEMBL186934 | — | — | 1 | 5.80 |
| CHEMBL186120 | — | — | 1 | 5.80 |
| CHEMBL186932 | — | — | 1 | 5.49 |
| CHEMBL363252 | — | — | 1 | 5.40 |
| CHEMBL434917 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL186342 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL186898 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL364213 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL363954 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL186470 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL184404 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL187256 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL187903 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL186240 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL365855 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL186371 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL359591 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL187015 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL364338 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL186511 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL426972 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL185734 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL186510 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL185470 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL363283 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL363711 | — | IC50 | = | 321.0 | nM | 6.49 |
| CHEMBL186846 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL185498 | — | IC50 | = | 621.0 | nM | 6.21 |
| CHEMBL186201 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL188172 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL186934 | — | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL186120 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL186932 | — | IC50 | = | 3270.0 | nM | 5.49 |
| CHEMBL363252 | — | IC50 | = | 3990.0 | nM | 5.40 |
| CHEMBL434917 | — | IC50 | = | 4580.0 | nM | 5.34 |
| CHEMBL186847 | — | IC50 | = | 6530.0 | nM | 5.18 |
| CHEMBL362369 | — | IC50 | = | 7670.0 | nM | 5.12 |