Assay Detail
Binding
CHEMBL832370
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In vitro inhibitory activity against [3H]-GABA transport in rat cerebrocortical membranes in the presence of NNC-711 (100 uM); Phase 1
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Publication
Novel secoergoline derivatives inhibit both GABA and glutamate uptake in rat brain homogenates: synthesis, in vitro pharmacology, and modeling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.51 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL534702 | — | — | 1 | 8.43 |
| CHEMBL540611 | — | — | 1 | 7.36 |
| CHEMBL558391 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL534702 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL540611 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL558391 | — | IC50 | = | 180.0 | nM | 6.75 |