Assay Detail
Binding
CHEMBL832404
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Inhibition of Cyclin-dependent kinase 4-cyclin D1
99
Total Activities
99
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 4/cyclin D1 (CHEMBL1907601) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of 1-aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of cyclin-dependent kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.38 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL187984 | — | — | 1 | 7.70 |
| CHEMBL425181 | — | — | 1 | 7.40 |
| CHEMBL363174 | — | — | 1 | 7.30 |
| CHEMBL187522 | — | — | 1 | 7.22 |
| CHEMBL187816 | — | — | 1 | 7.10 |
| CHEMBL418203 | — | — | 1 | 7.05 |
| CHEMBL364001 | — | — | 1 | 6.80 |
| CHEMBL536272 | — | — | 1 | 6.34 |
| CHEMBL1790020 | — | — | 1 | 6.23 |
| CHEMBL363172 | — | — | 1 | 6.03 |
| CHEMBL365144 | — | — | 1 | 5.96 |
| CHEMBL365713 | — | — | 1 | 5.89 |
| CHEMBL188587 | — | — | 1 | 5.89 |
| CHEMBL433590 | — | — | 1 | 5.77 |
| CHEMBL188650 | — | — | 1 | 5.70 |
| CHEMBL366209 | — | — | 1 | 5.68 |
| CHEMBL370283 | — | — | 1 | 5.68 |
| CHEMBL186157 | — | — | 1 | 5.66 |
| CHEMBL364435 | — | — | 1 | 5.62 |
| CHEMBL363679 | — | — | 1 | 5.57 |
| CHEMBL190636 | — | — | 1 | 5.54 |
| CHEMBL187433 | — | — | 1 | 5.54 |
| CHEMBL190317 | — | — | 1 | 5.54 |
| CHEMBL362075 | — | — | 1 | 5.52 |
| CHEMBL188863 | — | — | 1 | 5.52 |
| CHEMBL187511 | — | — | 1 | 5.51 |
| CHEMBL373298 | — | — | 1 | 5.46 |
| CHEMBL188102 | — | — | 1 | 5.44 |
| CHEMBL187353 | — | — | 1 | 5.37 |
| CHEMBL191312 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL187984 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL425181 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL363174 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL187522 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL187816 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL418203 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL364001 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL536272 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL1790020 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL363172 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL365144 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL365713 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL188587 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL433590 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL188650 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL366209 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL370283 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL186157 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL364435 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL363679 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL190636 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL187433 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL190317 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL362075 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL188863 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL187511 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL373298 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL188102 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL187353 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL191312 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL433959 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL189333 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL424810 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL187708 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL362121 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL189332 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL187762 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL363715 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL363689 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL187949 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL190091 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL187352 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL188812 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL190323 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL189711 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL188441 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL190738 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL187983 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL435693 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL187351 | — | IC50 | = | 19000.0 | nM | 4.72 |