Assay Detail
Functional
CHEMBL832410
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Inhibitory activity against murine mixed lymphocyte reaction
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
A locally active antiinflammatory macrolide (MLD987) for inhalation therapy of asthma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.78 | 9.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269732 | TACROLIMUS ANHYDROUS | 4.0 | 1 | 9.54 |
| CHEMBL411735 | — | — | 1 | 8.79 |
| CHEMBL265123 | — | — | 1 | 8.01 |
| CHEMBL1370 | BUDESONIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269732 | TACROLIMUS ANHYDROUS | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL411735 | — | IC50 | = | 1.62 | nM | 8.79 |
| CHEMBL265123 | — | IC50 | = | 9.81 | nM | 8.01 |
| CHEMBL1370 | BUDESONIDE | IC50 | - | nM | - |