Assay Detail
Binding
CHEMBL832427
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Inhibition of [3H]-Ro-25-6981 binding to NMDA receptor
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Oxamides as novel NR2B selective NMDA receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.84 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL219631 | BESONPRODIL | -1.0 | 1 | 8.40 |
| CHEMBL317229 | — | — | 1 | 8.40 |
| CHEMBL363010 | — | — | 1 | 8.40 |
| CHEMBL363722 | — | — | 1 | 8.30 |
| CHEMBL182066 | RADIPRODIL | 2.0 | 1 | 8.22 |
| CHEMBL305195 | — | — | 1 | 8.22 |
| CHEMBL17350 | TRAXOPRODIL | 2.0 | 1 | 8.15 |
| CHEMBL182698 | — | — | 1 | 8.10 |
| CHEMBL182665 | — | — | 1 | 8.10 |
| CHEMBL360373 | — | — | 1 | 7.80 |
| CHEMBL183825 | — | — | 1 | 7.77 |
| CHEMBL182951 | — | — | 1 | 7.77 |
| CHEMBL183457 | — | — | 1 | 7.77 |
| CHEMBL183142 | — | — | 1 | 7.58 |
| CHEMBL126228 | — | — | 1 | 7.51 |
| CHEMBL367816 | — | — | 1 | 7.40 |
| CHEMBL185812 | — | — | 1 | 7.27 |
| CHEMBL360463 | — | — | 1 | 6.88 |
| CHEMBL182369 | — | — | 1 | 6.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL219631 | BESONPRODIL | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL317229 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL363010 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL363722 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL182066 | RADIPRODIL | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL305195 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL17350 | TRAXOPRODIL | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL182698 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL182665 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL360373 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL183825 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL182951 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL183457 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL183142 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL126228 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL367816 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL185812 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL360463 | — | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL182369 | — | IC50 | = | 139.0 | nM | 6.86 |