Assay Detail
Binding
CHEMBL832432
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of aldose reductase from pig lenses
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL4559) ↗| Type | SINGLE PROTEIN |
| Organism | Sus scrofa |
Publication
Soft docking and multiple receptor conformations in virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.86 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL436 | TOLRESTAT | 4.0 | 1 | 7.52 |
| CHEMBL266497 | SORBINIL | 3.0 | 1 | 5.96 |
| CHEMBL188253 | — | — | 1 | 5.10 |
| CHEMBL186124 | — | — | 1 | 4.85 |
| CHEMBL186174 | — | — | 1 | - |
| CHEMBL187527 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL436 | TOLRESTAT | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL266497 | SORBINIL | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL188253 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL186124 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL186174 | — | IC50 | = | 336000.0 | nM | - |
| CHEMBL187527 | — | IC50 | = | 274000.0 | nM | - |