Assay Detail
Binding
CHEMBL832459
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Inhibitory activity against human Thyroid hormone receptor beta
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Thyroid receptor ligands. 3. Design and synthesis of 3,5-dihalo-4-alkoxyphenylalkanoic acids as indirect antagonists of the thyroid hormone receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.77 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL192427 | — | — | 1 | 6.72 |
| CHEMBL195556 | — | — | 1 | 6.44 |
| CHEMBL425557 | — | — | 1 | 6.22 |
| CHEMBL192142 | — | — | 1 | 6.11 |
| CHEMBL425366 | — | — | 1 | 6.10 |
| CHEMBL192426 | — | — | 1 | 6.09 |
| CHEMBL193198 | — | — | 1 | 6.04 |
| CHEMBL192639 | — | — | 1 | 5.82 |
| CHEMBL195855 | — | — | 1 | 5.75 |
| CHEMBL192490 | — | — | 1 | 5.72 |
| CHEMBL157885 | — | — | 1 | 5.29 |
| CHEMBL193152 | — | — | 1 | 5.24 |
| CHEMBL192508 | — | — | 1 | 4.75 |
| CHEMBL192346 | — | — | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL192427 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL195556 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL425557 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL192142 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL425366 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL192426 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL193198 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL192639 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL195855 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL192490 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL157885 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL193152 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL192508 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL192346 | — | IC50 | = | 32000.0 | nM | 4.50 |