Assay Detail
Binding
CHEMBL832469
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Inhibitory concentration against integration of HIV-1 Integrase
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and biological evaluation of geminal disulfones as HIV-1 integrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.91 | 6.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19977 | — | — | 1 | 6.32 |
| CHEMBL190009 | — | — | 1 | 6.05 |
| CHEMBL191020 | — | — | 1 | 5.30 |
| CHEMBL191445 | — | — | 1 | 5.30 |
| CHEMBL189892 | — | — | 1 | 4.52 |
| CHEMBL188746 | — | — | 1 | 4.30 |
| CHEMBL373133 | — | — | 1 | 4.16 |
| CHEMBL189982 | — | — | 1 | 4.10 |
| CHEMBL191022 | — | — | 1 | 4.10 |
| CHEMBL191200 | — | — | 1 | - |
| CHEMBL373310 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19977 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL190009 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL191020 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL191445 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL189892 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL188746 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL373133 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL189982 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL191022 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL191200 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL373310 | — | IC50 | = | 700000.0 | nM | - |