Assay Detail
Functional
CHEMBL832508
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Beta-secretase inhibitory activity as inhibition of secreted alkaline phosphatase in HEK293 cells expressing SEAP-APP fusion protein
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Publication
Discovery of cell-permeable non-peptide inhibitors of beta-secretase by high-throughput docking and continuum electrostatics calculations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.71 | 7.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190346 | — | — | 1 | 7.94 |
| CHEMBL190644 | — | — | 1 | 7.63 |
| CHEMBL363539 | — | — | 1 | 4.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190346 | — | EC50 | = | 11.4 | nM | 7.94 |
| CHEMBL190644 | — | EC50 | = | 23.3 | nM | 7.63 |
| CHEMBL363539 | — | EC50 | = | 27000.0 | nM | 4.57 |