Assay Detail
Functional
CHEMBL832509
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration for activation of human Opioid receptor kappa 1 expressed in chinese hamster ovary cells to enhance [35S]GTP-gamma-S, binding
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | ovary |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and in vitro pharmacological evaluation of salvinorin A analogues modified at C(2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 7.28 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL445332 | SALVINORIN A | 1.0 | 1 | 8.35 |
| CHEMBL290543 | — | — | 1 | 8.35 |
| CHEMBL3349979 | — | — | 1 | 8.21 |
| CHEMBL379138 | — | — | 1 | 8.00 |
| CHEMBL378635 | DEOXY SALVINORIN A | — | 1 | 7.73 |
| CHEMBL370272 | — | — | 1 | 7.69 |
| CHEMBL255969 | SALVINORIN A PROPYL ETHER | — | 1 | 7.17 |
| CHEMBL384411 | — | — | 1 | 7.16 |
| CHEMBL3349980 | — | — | 1 | 6.98 |
| CHEMBL3349984 | — | — | 1 | 6.84 |
| CHEMBL3349987 | — | — | 1 | 6.79 |
| CHEMBL3349983 | — | — | 1 | 6.70 |
| CHEMBL213567 | — | — | 1 | 6.46 |
| CHEMBL424698 | SALVINORIN B | — | 1 | 6.43 |
| CHEMBL413774 | — | — | 1 | 6.41 |
| CHEMBL3219942 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL445332 | SALVINORIN A | EC50 | = | 4.5 | nM | 8.35 |
| CHEMBL290543 | — | EC50 | = | 4.5 | nM | 8.35 |
| CHEMBL3349979 | — | EC50 | = | 6.2 | nM | 8.21 |
| CHEMBL379138 | — | EC50 | = | 9.9 | nM | 8.00 |
| CHEMBL378635 | DEOXY SALVINORIN A | EC50 | = | 18.6 | nM | 7.73 |
| CHEMBL370272 | — | EC50 | = | 20.4 | nM | 7.69 |
| CHEMBL255969 | SALVINORIN A PROPYL ETHER | EC50 | = | 67.4 | nM | 7.17 |
| CHEMBL384411 | — | EC50 | = | 68.9 | nM | 7.16 |
| CHEMBL3349980 | — | EC50 | = | 104.0 | nM | 6.98 |
| CHEMBL3349984 | — | EC50 | = | 145.0 | nM | 6.84 |
| CHEMBL3349987 | — | EC50 | = | 161.0 | nM | 6.79 |
| CHEMBL3349983 | — | EC50 | = | 201.0 | nM | 6.70 |
| CHEMBL213567 | — | EC50 | = | 343.0 | nM | 6.46 |
| CHEMBL424698 | SALVINORIN B | EC50 | = | 371.0 | nM | 6.43 |
| CHEMBL413774 | — | EC50 | = | 389.0 | nM | 6.41 |
| CHEMBL3219942 | — | EC50 | > | 1000.0 | nM | - |