Assay Detail
Binding
CHEMBL832566
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Inhibitory concentration of triacylgylcerol hydrolase using FP-Rh radioligand
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.77 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL413727 | — | — | 1 | 9.30 |
| CHEMBL91416 | — | — | 1 | 9.00 |
| CHEMBL175854 | — | — | 1 | 9.00 |
| CHEMBL93675 | — | — | 1 | 8.70 |
| CHEMBL367966 | — | — | 1 | 8.52 |
| CHEMBL179760 | — | — | 1 | 8.30 |
| CHEMBL182199 | — | — | 1 | 8.30 |
| CHEMBL91417 | — | — | 1 | 8.30 |
| CHEMBL361170 | — | — | 1 | 8.00 |
| CHEMBL90258 | — | — | 1 | 8.00 |
| CHEMBL366907 | — | — | 1 | 7.70 |
| CHEMBL180625 | — | — | 1 | 7.52 |
| CHEMBL424976 | — | — | 1 | 7.52 |
| CHEMBL90308 | — | — | 1 | 7.16 |
| CHEMBL178398 | — | — | 1 | 6.85 |
| CHEMBL182206 | — | — | 1 | 6.70 |
| CHEMBL361529 | — | — | 1 | 6.30 |
| CHEMBL177577 | — | — | 1 | 6.22 |
| CHEMBL177708 | — | — | 1 | 6.00 |
| CHEMBL35925 | — | — | 1 | 6.00 |
| CHEMBL366959 | — | — | 1 | 5.70 |
| CHEMBL89946 | — | — | 1 | 5.34 |
| CHEMBL329187 | — | — | 1 | 5.30 |
| CHEMBL177216 | — | — | 1 | 5.22 |
| CHEMBL39412 | — | — | 1 | 5.05 |
| CHEMBL285678 | — | — | 1 | 5.00 |
| CHEMBL178563 | — | — | 1 | 4.70 |
| CHEMBL362705 | — | — | 1 | 4.70 |
| CHEMBL426230 | — | — | 1 | 4.30 |
| CHEMBL426410 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL413727 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL91416 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL175854 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL93675 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL367966 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL179760 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL182199 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL91417 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL361170 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL90258 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL366907 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL180625 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL424976 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL90308 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL178398 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL182206 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL361529 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL177577 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL177708 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL35925 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL366959 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL89946 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL329187 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL177216 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL39412 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL285678 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL178563 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL362705 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL426230 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL426410 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL181187 | — | IC50 | - | nM | - |