Assay Detail
Binding
CHEMBL832595
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Inhibitory activity against prolyl oligopeptidase of porcine brain homogenate
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A cyclopent-2-enecarbonyl group mimics proline at the P2 position of prolyl oligopeptidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.64 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76578 | — | — | 1 | 9.70 |
| CHEMBL189620 | — | — | 1 | 9.70 |
| CHEMBL185848 | — | — | 1 | 9.70 |
| CHEMBL365843 | — | — | 1 | 9.52 |
| CHEMBL186979 | — | — | 1 | 8.89 |
| CHEMBL289651 | — | — | 1 | 8.66 |
| CHEMBL363530 | — | — | 1 | 8.30 |
| CHEMBL189463 | — | — | 1 | 8.05 |
| CHEMBL363335 | — | — | 1 | 7.28 |
| CHEMBL186622 | — | — | 1 | 6.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76578 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL189620 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL185848 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL365843 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL186979 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL289651 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL363530 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL189463 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL363335 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL186622 | — | IC50 | = | 230.0 | nM | 6.64 |