Assay Detail
Binding
CHEMBL832620
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In vitro inhibitory concentration against phospholipase A2 of Trimeresurus flavoviridis venom
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trimeresurus flavoviridis |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Basic phospholipase A2 PLA-A (CHEMBL5022) ↗| Type | SINGLE PROTEIN |
| Organism | Trimeresurus flavoviridis |
Publication
Synthesis of benzoyl phenyl benzoates as effective inhibitors for phospholipase A2 and hyaluronidase enzymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.65 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL169 | URSOLIC ACID | 2.0 | 1 | 5.60 |
| CHEMBL188295 | — | — | 1 | 5.60 |
| CHEMBL365712 | — | — | 1 | 4.34 |
| CHEMBL186940 | — | — | 1 | 4.16 |
| CHEMBL425541 | — | — | 1 | 4.12 |
| CHEMBL187531 | — | — | 1 | 4.05 |
| CHEMBL187905 | — | — | 1 | - |
| CHEMBL189359 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL169 | URSOLIC ACID | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL188295 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL365712 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL186940 | — | IC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL425541 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL187531 | — | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL187905 | — | IC50 | = | 108000.0 | nM | - |
| CHEMBL189359 | — | IC50 | = | 139000.0 | nM | - |