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Assay Detail

CHEMBL832630

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory concentration against 20S proteasome chymotrypsin-like activity
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 2 — Organism
Curated By Expert

Target

Proteasome (CHEMBL612443)
Type SUBCELLULAR

Publication

Retro hydrazino-azapeptoids as peptidomimetics of proteasome inhibitors.
Aubin S, Martin B, Delcros JG, Arlot-Bonnemains Y, Baudy-Floc'h M.
J Med Chem (2005) 48 : 330 -334
PubMed 15634028 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 4.21 4.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL433563 1 4.30
CHEMBL179042 1 4.28
CHEMBL360115 1 4.04
CHEMBL180069 1 -
CHEMBL179077 1 -
CHEMBL369089 1 -
CHEMBL367790 1 -
CHEMBL180332 1 -
CHEMBL178713 1 -
CHEMBL175460 1 -
CHEMBL178570 1 -
CHEMBL178550 1 -
CHEMBL178579 1 -
CHEMBL179078 1 -
CHEMBL178533 1 -
CHEMBL179153 1 -
CHEMBL264460 1 -
CHEMBL361823 1 -
CHEMBL178350 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL433563 IC50 = 50000.0 nM 4.30
CHEMBL179042 IC50 = 53000.0 nM 4.28
CHEMBL360115 IC50 = 91000.0 nM 4.04
CHEMBL180069 IC50 > 1000000.0 nM -
CHEMBL179077 IC50 > 1000000.0 nM -
CHEMBL369089 IC50 > 1000000.0 nM -
CHEMBL367790 IC50 > 1000000.0 nM -
CHEMBL180332 IC50 > 1000000.0 nM -
CHEMBL178713 IC50 > 1000000.0 nM -
CHEMBL175460 IC50 > 1000000.0 nM -
CHEMBL178570 IC50 > 1000000.0 nM -
CHEMBL178550 IC50 > 1000000.0 nM -
CHEMBL178579 IC50 = 350000.0 nM -
CHEMBL179078 IC50 > 1000000.0 nM -
CHEMBL178533 IC50 = 500000.0 nM -
CHEMBL179153 IC50 > 1000000.0 nM -
CHEMBL264460 IC50 > 1000000.0 nM -
CHEMBL361823 IC50 > 1000000.0 nM -
CHEMBL178350 IC50 > 1000000.0 nM -