Assay Detail
Binding
CHEMBL832661
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [gamma-32P]-ATP binding to protein kinase C (1.5 ng) done for 10 min in pH 7.4 at 37 degree C with compound dissolved in DMSO using in In-Plate assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis, modeling, and in vitro activity of (3'S)-epi-K-252a analogues. Elucidating the stereochemical requirements of the 3'-sugar alcohol on trkA tyrosine kinase activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.63 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370493 | — | — | 1 | 7.10 |
| CHEMBL94678 | — | — | 1 | 6.94 |
| CHEMBL2113064 | — | — | 1 | 6.94 |
| CHEMBL365585 | — | — | 1 | 6.66 |
| CHEMBL281948 | K-252A | — | 1 | 6.60 |
| CHEMBL2113062 | — | — | 1 | 6.51 |
| CHEMBL2113065 | — | — | 1 | 6.18 |
| CHEMBL2113063 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370493 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL94678 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL2113064 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL365585 | — | IC50 | = | 218.0 | nM | 6.66 |
| CHEMBL281948 | K-252A | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL2113062 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL2113065 | — | IC50 | = | 663.0 | nM | 6.18 |
| CHEMBL2113063 | — | IC50 | = | 850.0 | nM | 6.07 |