Assay Detail
Binding
CHEMBL832665
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Inhibitory concentration against herpes simplex virus type 1 thymidine kinase
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | herpes simplex virus type 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Thymidine kinase (CHEMBL1820) ↗| Type | SINGLE PROTEIN |
| Organism | Human herpesvirus 1 (strain SC16) (HHV-1) (Human herpes simplex virus1) |
Publication
Inhibition of herpes simplex virus thymidine kinases by 2-phenylamino-6-oxopurines and related compounds: structure-activity relationships and antiherpetic activity in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.59 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL557599 | — | — | 1 | 6.82 |
| CHEMBL558363 | — | — | 1 | 6.46 |
| CHEMBL558983 | — | — | 1 | 6.39 |
| CHEMBL425913 | — | — | 1 | 6.30 |
| CHEMBL538319 | — | — | 1 | 6.26 |
| CHEMBL372171 | — | — | 1 | 6.12 |
| CHEMBL534929 | — | — | 1 | 6.11 |
| CHEMBL557571 | — | — | 1 | 6.00 |
| CHEMBL195167 | — | — | 1 | 6.00 |
| CHEMBL406254 | — | — | 1 | 5.89 |
| CHEMBL538078 | — | — | 1 | 5.80 |
| CHEMBL537633 | — | — | 1 | 5.70 |
| CHEMBL192246 | — | — | 1 | 5.70 |
| CHEMBL557156 | — | — | 1 | 5.68 |
| CHEMBL559182 | — | — | 1 | 5.64 |
| CHEMBL538570 | — | — | 1 | 5.60 |
| CHEMBL534931 | — | — | 1 | 5.44 |
| CHEMBL347128 | — | — | 1 | 5.36 |
| CHEMBL541128 | — | — | 1 | 5.35 |
| CHEMBL534708 | — | — | 1 | 5.33 |
| CHEMBL535149 | — | — | 1 | 5.28 |
| CHEMBL537410 | — | — | 1 | 5.24 |
| CHEMBL558963 | — | — | 1 | 5.15 |
| CHEMBL536959 | — | — | 1 | 5.09 |
| CHEMBL192209 | — | — | 1 | 4.92 |
| CHEMBL362939 | — | — | 1 | 4.82 |
| CHEMBL193062 | — | — | 1 | 4.80 |
| CHEMBL556363 | — | — | 1 | 4.78 |
| CHEMBL258513 | — | — | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL557599 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL558363 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL558983 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL425913 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL538319 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL372171 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL534929 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL557571 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL195167 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL406254 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL538078 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL537633 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL192246 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL557156 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL559182 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL538570 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL534931 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL347128 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL541128 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL534708 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL535149 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL537410 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL558963 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL536959 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL192209 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL362939 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL193062 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL556363 | — | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL258513 | — | IC50 | = | 60000.0 | nM | 4.22 |