Assay Detail
Binding
CHEMBL832698
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Mitogen-activated protein kinase 1
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase; ERK1/ERK2 (CHEMBL1907606) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.24 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL261720 | — | — | 1 | 6.00 |
| CHEMBL363130 | — | — | 1 | 5.23 |
| CHEMBL363607 | — | — | 1 | 5.02 |
| CHEMBL191003 | JNJ-7706621 | — | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL261720 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL363130 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL363607 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL191003 | JNJ-7706621 | IC50 | = | 19400.0 | nM | 4.71 |