Assay Detail
Binding
CHEMBL832706
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of glycogen synthase kinase 3
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.88 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 6.55 |
| CHEMBL31574 | FISETIN | 2.0 | 1 | 6.38 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 6.10 |
| CHEMBL28 | APIGENIN | — | 1 | 5.85 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 5.68 |
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | 5.46 |
| CHEMBL117 | CHRYSIN | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428690 | ALVOCIDIB | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL31574 | FISETIN | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL151 | LUTEOLIN | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL28 | APIGENIN | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL50 | QUERCETIN | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL150 | KAEMPFEROL | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL117 | CHRYSIN | IC50 | = | 7200.0 | nM | 5.14 |