Assay Detail
Binding
CHEMBL832760
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Concentration required to inhibit [125I]MCP-1 binding to Chemokine receptor 2B
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Small molecule antagonists of the CCR2b receptor. Part 2: Discovery process and initial structure-activity relationships of diamine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.08 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL255408 | — | — | 1 | 6.75 |
| CHEMBL365681 | — | — | 1 | 6.43 |
| CHEMBL2096788 | — | — | 1 | 6.24 |
| CHEMBL181432 | — | — | 1 | 6.18 |
| CHEMBL435499 | — | — | 1 | 6.16 |
| CHEMBL182958 | — | — | 1 | 6.15 |
| CHEMBL2096789 | — | — | 1 | 5.92 |
| CHEMBL365854 | — | — | 1 | 5.64 |
| CHEMBL2448120 | — | — | 1 | 5.51 |
| CHEMBL187469 | — | — | 1 | 5.26 |
| CHEMBL363908 | — | — | 1 | 5.16 |
| CHEMBL186855 | — | — | 1 | 5.13 |
| CHEMBL362536 | — | — | 1 | 5.11 |
| CHEMBL187476 | — | — | 1 | 4.96 |
| CHEMBL183681 | — | — | 1 | 4.96 |
| CHEMBL186878 | — | — | 1 | 4.85 |
| CHEMBL362780 | — | — | 1 | 4.77 |
| CHEMBL185518 | — | — | 1 | 4.77 |
| CHEMBL362340 | — | — | 1 | 4.72 |
| CHEMBL187237 | — | — | 1 | 4.66 |
| CHEMBL446178 | — | — | 1 | 4.58 |
| CHEMBL184240 | — | — | 1 | 4.48 |
| CHEMBL185283 | — | — | 1 | 4.40 |
| CHEMBL186984 | — | — | 1 | 4.39 |
| CHEMBL188170 | — | — | 1 | 4.38 |
| CHEMBL184220 | — | — | 1 | 4.30 |
| CHEMBL185190 | — | — | 1 | 4.19 |
| CHEMBL184474 | — | — | 1 | 4.18 |
| CHEMBL364405 | — | — | 1 | 4.13 |
| CHEMBL363994 | — | — | 1 | 4.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL255408 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL365681 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL2096788 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL181432 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL435499 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL182958 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL2096789 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL365854 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL2448120 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL187469 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL363908 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL186855 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL362536 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL187476 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL183681 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL186878 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL362780 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL185518 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL362340 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL187237 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL446178 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL184240 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL185283 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL186984 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL188170 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL184220 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL185190 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL184474 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL364405 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL363994 | — | IC50 | = | 87000.0 | nM | 4.06 |