Assay Detail
Binding
CHEMBL832812
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against HMG-CoA reductase
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
3-hydroxy-3-methylglutaryl-coenzyme A reductase (CHEMBL402) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Molecular docking of the highly hypolipidemic agent alpha-asarone with the catalytic portion of HMG-CoA reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.21 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1496 | ROSUVASTATIN | 4.0 | 1 | 8.27 |
| CHEMBL1064 | SIMVASTATIN | 4.0 | 1 | 7.95 |
| CHEMBL50444 | MEGLUTOL | 2.0 | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1496 | ROSUVASTATIN | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL1064 | SIMVASTATIN | IC50 | = | 11.2 | nM | 7.95 |
| CHEMBL50444 | MEGLUTOL | IC50 | = | 4000.0 | nM | 5.40 |