Assay Detail
Binding
CHEMBL832821
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Inhibition of Phosphodiesterase 4
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Fused pyrimidine based inhibitors of phosphodiesterase 7 (PDE7): synthesis and initial structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.05 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL183726 | — | — | 1 | 6.57 |
| CHEMBL100503 | — | — | 1 | 6.26 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 6.13 |
| CHEMBL362451 | — | — | 1 | 5.96 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL183726 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL100503 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL362451 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL192 | SILDENAFIL | IC50 | = | 4600.0 | nM | 5.34 |