Assay Detail
Binding
CHEMBL832823
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Inhibition of Phosphodiesterase 7
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Fused pyrimidine based inhibitors of phosphodiesterase 7 (PDE7): synthesis and initial structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.43 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL100503 | — | — | 1 | 7.96 |
| CHEMBL183726 | — | — | 1 | 7.05 |
| CHEMBL362451 | — | — | 1 | 6.82 |
| CHEMBL183766 | — | — | 1 | 6.47 |
| CHEMBL181463 | — | — | 1 | 5.30 |
| CHEMBL183827 | — | — | 1 | 5.22 |
| CHEMBL183445 | — | — | 1 | 4.70 |
| CHEMBL367577 | — | — | 1 | 4.70 |
| CHEMBL361830 | — | — | 1 | 4.52 |
| CHEMBL182953 | — | — | 1 | 4.22 |
| CHEMBL181209 | — | — | 1 | 4.16 |
| CHEMBL181530 | — | — | 1 | 4.00 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | - |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | - |
| CHEMBL362022 | — | — | 1 | - |
| CHEMBL179894 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL100503 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL183726 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL362451 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL183766 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL181463 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL183827 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL183445 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL367577 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL361830 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL182953 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL181209 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL181530 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL63 | ROLIPRAM | IC50 | > | 10000.0 | nM | - |
| CHEMBL192 | SILDENAFIL | IC50 | > | 10000.0 | nM | - |
| CHEMBL362022 | — | IC50 | = | 150000.0 | nM | - |
| CHEMBL179894 | — | IC50 | = | 150000.0 | nM | - |