Assay Detail
Binding
CHEMBL832923
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human cyclin-dependent kinase 6 complex with a virus-encoded cyclin from herpesvirus saimiri (Vcyclin)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.57 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 7.10 |
| CHEMBL31574 | FISETIN | 2.0 | 1 | 6.07 |
| CHEMBL28 | APIGENIN | — | 1 | 5.77 |
| CHEMBL117 | CHRYSIN | — | 1 | 5.22 |
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | 4.66 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 4.60 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428690 | ALVOCIDIB | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL31574 | FISETIN | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL28 | APIGENIN | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL117 | CHRYSIN | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL150 | KAEMPFEROL | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL50 | QUERCETIN | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL151 | LUTEOLIN | IC50 | > | 300000.0 | nM | - |