Assay Detail
Binding
CHEMBL832927
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Inhibitory concentration for Glycogen synthase kinase-3 beta was determined in the presence of 10 um ATP (Km 50 uM)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.06 | 6.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL360573 | — | — | 1 | 6.34 |
| CHEMBL178785 | — | — | 1 | 5.47 |
| CHEMBL181114 | — | — | 1 | 5.40 |
| CHEMBL367150 | — | — | 1 | 5.29 |
| CHEMBL361833 | — | — | 1 | 5.28 |
| CHEMBL178769 | — | — | 1 | 5.06 |
| CHEMBL178268 | — | — | 1 | 4.92 |
| CHEMBL178179 | — | — | 1 | 4.66 |
| CHEMBL180814 | — | — | 1 | 4.55 |
| CHEMBL361348 | — | — | 1 | 4.40 |
| CHEMBL361231 | — | — | 1 | 4.30 |
| CHEMBL181293 | — | — | 1 | - |
| CHEMBL180714 | — | — | 1 | - |
| CHEMBL181606 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL360573 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL178785 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL181114 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL367150 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL361833 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL178769 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL178268 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL178179 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL180814 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL361348 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL361231 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL181293 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL180714 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL181606 | — | IC50 | > | 50000.0 | nM | - |