Assay Detail
Binding
CHEMBL832953
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Inhibition of Src protein tyrosine kinase in LANCE format enzyme assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and Src kinase inhibitory activity of 2-phenyl- and 2-thienyl-7-phenylaminothieno[3,2-b]pyridine-6-carbonitriles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.52 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 8.42 |
| CHEMBL194664 | — | — | 1 | 8.14 |
| CHEMBL363575 | — | — | 1 | 8.14 |
| CHEMBL410251 | — | — | 1 | 8.13 |
| CHEMBL195419 | — | — | 1 | 8.09 |
| CHEMBL194503 | — | — | 1 | 8.06 |
| CHEMBL370473 | — | — | 1 | 8.04 |
| CHEMBL190981 | — | — | 1 | 7.96 |
| CHEMBL364955 | — | — | 1 | 7.89 |
| CHEMBL195382 | — | — | 1 | 7.89 |
| CHEMBL192052 | — | — | 1 | 7.85 |
| CHEMBL372219 | — | — | 1 | 7.82 |
| CHEMBL425382 | — | — | 1 | 7.77 |
| CHEMBL194992 | — | — | 1 | 7.64 |
| CHEMBL192652 | — | — | 1 | 7.60 |
| CHEMBL426990 | — | — | 1 | 7.47 |
| CHEMBL425371 | — | — | 1 | 7.30 |
| CHEMBL373132 | — | — | 1 | 7.28 |
| CHEMBL195157 | — | — | 1 | 7.28 |
| CHEMBL366029 | — | — | 1 | 7.17 |
| CHEMBL194815 | — | — | 1 | 6.96 |
| CHEMBL192679 | — | — | 1 | 6.85 |
| CHEMBL195523 | — | — | 1 | 6.38 |
| CHEMBL195046 | — | — | 1 | 6.01 |
| CHEMBL365398 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288441 | BOSUTINIB | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL194664 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL363575 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL410251 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL195419 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL194503 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL370473 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL190981 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL364955 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL195382 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL192052 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL372219 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL425382 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL194992 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL192652 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL426990 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL425371 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL373132 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL195157 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL366029 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL194815 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL192679 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL195523 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL195046 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL365398 | — | IC50 | = | 1300.0 | nM | 5.89 |