Assay Detail
Binding
CHEMBL832973
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Inhibitory concentration against activity of Hsp90 was determined by fluorescence polarization (FP) assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.65 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL365617 | — | — | 1 | 7.60 |
| CHEMBL424811 | — | — | 1 | 7.41 |
| CHEMBL366215 | — | — | 1 | 7.28 |
| CHEMBL364968 | — | — | 1 | 7.21 |
| CHEMBL190182 | — | — | 1 | 7.16 |
| CHEMBL365700 | — | — | 1 | 6.92 |
| CHEMBL371380 | — | — | 1 | 6.82 |
| CHEMBL191074 | — | — | 1 | 6.68 |
| CHEMBL399530 | — | — | 1 | 6.55 |
| CHEMBL426446 | — | — | 1 | 6.29 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 5.90 |
| CHEMBL192894 | — | — | 1 | 5.36 |
| CHEMBL188965 | — | — | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL365617 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL424811 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL366215 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL364968 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL190182 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL365700 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL371380 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL191074 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL399530 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL426446 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL192894 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL188965 | — | IC50 | = | 4730.0 | nM | 5.33 |