Assay Detail
Binding
CHEMBL832987
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Inhibition of trypsin like activity of the proteasome purified from lymphoblastoid cell lines (in vitro)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 2 — Organism |
| Curated By | Expert |
Publication
Peptidyl vinyl ester derivatives: new class of selective inhibitors of proteasome trypsin-like activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.92 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL188918 | — | — | 1 | 7.48 |
| CHEMBL189919 | — | — | 1 | 7.39 |
| CHEMBL188781 | — | — | 1 | 7.15 |
| CHEMBL188385 | — | — | 1 | 6.96 |
| CHEMBL189348 | — | — | 1 | 6.72 |
| CHEMBL426081 | — | — | 1 | 6.68 |
| CHEMBL365912 | — | — | 1 | 6.55 |
| CHEMBL188437 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL188918 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL189919 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL188781 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL188385 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL189348 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL426081 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL365912 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL188437 | — | IC50 | = | 380.0 | nM | 6.42 |