Assay Detail
Binding
CHEMBL833000
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Inhibitory concentration against human cathepsin B using 10 uM Cbz-Phe-Arg-AMC
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel and potent cyclic cyanamide-based cathepsin K inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.57 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL183812 | — | — | 1 | 8.62 |
| CHEMBL180839 | — | — | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL183812 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL180839 | — | IC50 | = | 310.0 | nM | 6.51 |