Assay Detail
Binding
CHEMBL833022
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory concentration against checkpoint kinase 2 (Chk2) by using [gamma-33P]-ATP] as radioligand
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Serine/threonine-protein kinase Chk2 (CHEMBL2527) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potent inhibition of checkpoint kinase activity by a hymenialdisine-derived indoloazepine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.41 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL332551 | — | — | 1 | 8.10 |
| CHEMBL361708 | HYMENIALDISINE | — | 1 | 7.38 |
| CHEMBL255465 | DEBROMOHYMENIALDISINE | — | 1 | 6.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL332551 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL361708 | HYMENIALDISINE | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL255465 | DEBROMOHYMENIALDISINE | IC50 | = | 183.0 | nM | 6.74 |