Assay Detail
Binding
CHEMBL833030
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against human 5-lipoxygenase
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
5-Lipoxygenase inhibition by N-hydroxycarbamates in dual-function compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.50 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL366925 | — | — | 1 | 6.77 |
| CHEMBL444083 | — | — | 1 | 6.71 |
| CHEMBL180233 | — | — | 1 | 6.47 |
| CHEMBL360666 | — | — | 1 | 6.46 |
| CHEMBL179590 | — | — | 1 | 6.44 |
| CHEMBL181085 | — | — | 1 | 6.38 |
| CHEMBL93 | ZILEUTON | 4.0 | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL366925 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL444083 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL180233 | — | IC50 | = | 335.0 | nM | 6.47 |
| CHEMBL360666 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL179590 | — | IC50 | = | 365.0 | nM | 6.44 |
| CHEMBL181085 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL93 | ZILEUTON | IC50 | = | 518.0 | nM | 6.29 |