Assay Detail
Binding
CHEMBL833039
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Inhibitory concentration against dipeptidylpeptidase 8
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel isoindoline compounds for potent and selective inhibition of prolyl dipeptidase DPP8.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.58 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL367368 | — | — | 1 | 7.85 |
| CHEMBL362018 | — | — | 1 | 7.80 |
| CHEMBL179289 | — | — | 1 | 7.72 |
| CHEMBL440021 | — | — | 1 | 7.62 |
| CHEMBL307636 | — | — | 1 | 7.57 |
| CHEMBL278393 | — | — | 1 | 7.11 |
| CHEMBL361107 | — | — | 1 | 6.82 |
| CHEMBL98408 | — | — | 1 | 6.44 |
| CHEMBL179845 | — | — | 1 | 6.26 |
| CHEMBL361863 | — | — | 1 | 5.94 |
| CHEMBL361235 | — | — | 1 | 5.52 |
| CHEMBL77538 | — | — | 1 | 5.34 |
| CHEMBL361551 | — | — | 1 | 5.22 |
| CHEMBL142703 | VILDAGLIPTIN | 4.0 | 1 | 4.85 |
| CHEMBL361758 | — | — | 1 | - |
| CHEMBL180664 | — | — | 1 | - |
| CHEMBL179996 | — | — | 1 | - |
| CHEMBL180000 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL367368 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL362018 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL179289 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL440021 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL307636 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL278393 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL361107 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL98408 | — | IC50 | = | 364.0 | nM | 6.44 |
| CHEMBL179845 | — | IC50 | = | 555.0 | nM | 6.26 |
| CHEMBL361863 | — | IC50 | = | 1148.0 | nM | 5.94 |
| CHEMBL361235 | — | IC50 | = | 3016.0 | nM | 5.52 |
| CHEMBL77538 | — | IC50 | = | 4573.0 | nM | 5.34 |
| CHEMBL361551 | — | IC50 | = | 5962.0 | nM | 5.22 |
| CHEMBL142703 | VILDAGLIPTIN | IC50 | = | 14219.0 | nM | 4.85 |
| CHEMBL361758 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL180664 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL179996 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL180000 | — | IC50 | > | 100000.0 | nM | - |